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KMID : 0882420050690000959
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Korean Journal of Medicine
2005 Volume.69 No. 0 p.959 ~ p.963
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A case of the ankylosing spondylitis presented with Henoch-Schonlein purpura
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Ryu Kyung-Hee
Chae Yun-Tae
Ko Eun-Hyang
Moon Jae-Hyun
Hong Sung-Kwan
Shim Jeong-Yun
Hong Seung-Jae
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Abstract
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Cutaneous leucocytoclastic vasculitis in patients with ankylosing spondylitis is rarely reported. Such an association might not be coincidental, as serum immunoglobulin A (Ig A) levels are reported to be high during the active inflammatory phases of ankylosing spondylitis and cutaneous leucocytoclastic vasculitis. But this finding supports the concept of abnormal Ig A immune stimulation in pathogenesis of ankylosing spondylitis and cutaneous leucocytoclastic vasculitis.
We report a 17 year-old male patient with ankylosing spondylitis accompanying with H-S purpura who initially presented with fever, abdominal pain, swelling and palpable pur-pura. Cutaneous biopsy showed neutrophilic infiltration of blood vessel wall with marked leukocytoclasia and fibrinoid necrosis of dermal vessels with extravased erythrocytes. The purpuric rash disappeared in one month without specific treatment. The patient was treated with indometacin and Sulfasalazine.(Korean J Med 69:S959-S963, 2005)
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KEYWORD
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Ankylosing spondylitis, Cutaneous leucocytoclastic vasculitis, Immuno-globulin A (IgA)
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